{"id":1462,"date":"2015-10-27T16:08:29","date_gmt":"2015-10-27T16:08:29","guid":{"rendered":"http:\/\/www.brainpreservation.org\/?p=1462"},"modified":"2015-10-29T18:45:40","modified_gmt":"2015-10-29T18:45:40","slug":"why-brain-emulation-is-coming-sooner-than-many-think-response-to-dr-miller-editorial","status":"publish","type":"post","link":"https:\/\/www.brainpreservation.org\/zh\/why-brain-emulation-is-coming-sooner-than-many-think-response-to-dr-miller-editorial\/","title":{"rendered":"Why Brain Emulation is Coming Sooner Than Many Think &#8211; A BPF Response to Dr. Miller&#8217;s NYT Editorial on Brain Emulation"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">Dr. Kenneth D. Miller, Co-Director of the Center for Theoretical Neuroscience at Columbia University, in a recent editorial in the <\/span><i><span style=\"font-weight: 400;\">New York Times,\u00a0<\/span><\/i><span style=\"font-weight: 400;\">\u201c<a href=\"http:\/\/www.nytimes.com\/2015\/10\/11\/opinion\/sunday\/will-you-ever-be-able-to-upload-your-brain.html?&amp;_r=0\" target=\"_blank\">Will You Ever Be Able to Upload Your Brain?<\/a>\u201d<\/span><span style=\"font-weight: 400;\">, \u00a0recently raised several skeptical arguments about the possibility of brain uploading. A key point to take away from this essay is that Dr. Miller actually agrees that successful brain emulation is possible and consistent with our current understanding of the brain. He says:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0\u00a0\u00a0\u201cI am a theoretical neuroscientist. I study models of brain circuits, precisely the sort of models that would be needed to try to reconstruct or emulate a functioning brain from a detailed knowledge of its structure. I don\u2019t in principle see any reason that what I\u2019ve described could not someday, in the very far future, be achieved.\u201d<\/span><\/p>\n<p>While Miller acknowledges the theoretical possibility of brain emulation, he is very skeptical about any near-term ability to do so, claiming that successfully emulating a human brain is not only infeasible with current and impending technologies (a claim no one would dispute), but that it will also vastly outstrip technological capabilities far into the future. We at the Brain Preservation Foundation (BPF) certainly agree that brain emulation presents tremendous challenges.\u00a0 For example, Kenneth Hayworth, President of the BPF, has described the resources and effort needed to emulate a human brain as akin to a \u201cmoon shot project,\u201d meaning that society would have to devote significant resources to the project over decades. However, such a projection contrasts starkly against Miller\u2019s suggestion that such a project could take \u201cthousands or even millions of years\u201d.<\/p>\n<p><span style=\"font-weight: 400;\">Two very promising techniques for brain preservation have recently been developed by BPF prize contenders, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26408851?dopt=Abstract\" target=\"_blank\">one by Dr. Robert McIntyre<\/a> and <a href=\"http:\/\/www.nature.com\/nmeth\/journal\/v12\/n6\/full\/nmeth.3361.html\" target=\"_blank\">another by Dr. Shawn Mikula<\/a><\/span><span style=\"font-weight: 400;\">. While it is still an open question, these methods are likely to preserve the connectome and all the molecular detail necessary for a person&#8217;s memory and identity; this is an exciting area of current research. Far from being pessimistic, we have every reason to be hopeful that validated and reliable human\u00a0brain preservation protocols will be developed in the next decade. Memory and identity theory and emulation research, for its part, will also continue to advance, and we have many reasons to expect\u00a0validated models for long-term memory storage, beginning in well-studied circuits in simple model organisms, again within the next decade.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">One reason for our considerably more optimistic predictions is that brain emulation relies on computing and other information technologies, fields that have classically enjoyed exponential gains in capability and should continue to do so for the foreseeable future. Computational neuroscience is now big science, and significant resources, above and beyond previous investments and commitments, are now being devoted to emulation. See for example the the EC-funded <a href=\"https:\/\/www.humanbrainproject.eu\/\" target=\"_blank\">Human Brain Project<\/a>. In basic neuroscience, new tools and funding have emerged for\u00a0mapping and understanding the connectome and the &#8220;synaptome,&#8221; Dr. Stephen Smith&#8217;s term for the deep synaptic diversity that exists at each synaptic bouton. See his presentation, <a href=\"https:\/\/www.youtube.com\/watch?v=J8FKSvVlzMI\" target=\"_blank\">The Synaptome Meets the Connectome<\/a>, 2012 (below), to appreciate how great this diversity\u00a0is, and how incomplete our models of it are\u00a0to date. Fortunately, new\u00a0funding for synaptic characterization, including\u00a0the NIH-funded <a href=\"http:\/\/braininitiative.nih.gov\/\" target=\"_blank\">BRAIN Initiative<\/a>, has also emerged<\/span><span style=\"font-weight: 400;\">. This increase in research and funding is driven by the need to better understand complicated mental illnesses as well as the general goal of bettering our understanding of the brain in both its structural and functional aspects. Therefore, our knowledge of the workings of the neuron and brain will continue to improve.<\/span><\/p>\n<p><iframe loading=\"lazy\" width=\"1140\" height=\"641\" src=\"https:\/\/www.youtube.com\/embed\/J8FKSvVlzMI?feature=oembed\" frameborder=\"0\" allowfullscreen><\/iframe><\/p>\n<p><span style=\"font-weight: 400;\">Miller also raises doubts as to whether it will ever be possible to preserve the brain for later scanning and emulation and states \u201cIt will almost certainly be a very long time before we can hope to preserve a brain in sufficient detail\u201d for accurate brain emulation.\u00a0Miller suggests that successfully emulating the brain may require extraordinary\u00a0detailed molecular knowledge of the state of every synapse and dendrite.\u00a0It is an ongoing question just how much detail is required to emulate a neuron, and it is not a foregone conclusion that dynamics at the scale of individual molecules are necessary; it is entirely possible that such molecular-scale properties are simply not critical to the larger stochastic behaviors of neurons. But if molecular-level detail for scanning and emulation turns out to be\u00a0necessary, a number of promising new protocols, such as\u00a0<a href=\"http:\/\/www.brainpreservation.org\/21cm-aldehyde-stabilized-cryopreservation-eval-page\/\">21st Century Medicine&#8217;s Aldehyde-Stabilized Cryopreservation<\/a>, may be\u00a0sufficient to the task, as aldehyde-stabilization via cerebrovascular perfusion is a process that can rapidly lock down all molecular activity in neurons within\u00a0minutes after death. This and other emerging protocols\u00a0may preserve cellular ultrastructure throughout an entire mammalian brain, a\u00a0claim the BPF was founded to assess. Accurate whole brain preservation is the central focus of the BPF, and rather than being a distant possibility it may soon be a reality.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Returning to emulation, another reason to be\u00a0optimistic that it is feasible sooner than many expect is that from an engineering perspective, the brain is a very noisy system, and therefore unlikely to rely on details at the scale of individual molecules, and it relies on considerable redundancy of structure and function. In contrast to what Miller suggests, cutting edge models of neurons currently used by computational neuroscience groups such as the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Blue_Brain_Project\" target=\"_blank\">Blue Brain Project<\/a> (for the paper, see\u00a0<\/span><span style=\"font-weight: 400;\"><a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867415011915\" target=\"_blank\">Markram etal. <em>Cell<\/em> 2015 Oct 8;163(2):456-492<\/a><\/span><span style=\"font-weight: 400;\">) model hundreds of aspects of the neuron using the software NEURON (<a href=\"https:\/\/www.neuron.yale.edu\/neuron\/static\/papers\/thensci\/spacetime_rev2.pdf\" target=\"_blank\">PDF here<\/a><\/span><span style=\"font-weight: 400;\">) and not \u201ca single fixed strength\u201d for synapses. Miller further claims the \u201cwash of chemicals from brainstem neurons that determine such things as when we are awake or attentive and when we are asleep, and by hormones from the body that help drive our motivations\u201d are problematic, but it is not clear why improved models of the brain can\u2019t include such properties in the future, if they are necessary. Miller further claims:<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0\u00a0\u00a0\u201cdendrites and synapses (and more), are constantly adapting to their electrical and chemical \u2018experience,\u2019 as part of learning, to maintain the ability to give appropriately different responses to different inputs, and to keep the brain stable and prevent seizures\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400;\">\u00a0\u00a0\u00a0\u201cThe connectome might give an average strength for each connection, but the actual strength varies over time.\u201d <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Again, we see no reason why all of these aspects, if relevant, would not be able to be\u00a0accounted for in future large-scale models of the brain if they turn out to be necessary. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">Furthermore, when we do neural emulation of any kind, we must also ask, \u201cemulation for what purpose?\u201d What features will we need to capture and \u201cupload\u201d from neurons to preserve their highest-level information? What subset of all neural structure and processes encodes, for example, our life\u2019s episodic memories? Neuroscience is still only beginning to ask such questions, which are critical to evaluating the future of uploading. <\/span><\/p>\n<div id=\"attachment_1469\" style=\"width: 310px\" class=\"wp-caption alignright\"><a href=\"http:\/\/www.brainpreservation.org\/wp-content\/uploads\/2015\/10\/BBPOffices.jpg\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1469\" class=\"size-medium wp-image-1469\" src=\"http:\/\/www.brainpreservation.org\/wp-content\/uploads\/2015\/10\/BBPOffices-300x200.jpg\" alt=\"Campus Biotech, offices of the Blue Brain Project of EPFL in Geneva, Switzerland\" width=\"300\" height=\"200\" srcset=\"https:\/\/www.brainpreservation.org\/wp-content\/uploads\/2015\/10\/BBPOffices-300x200.jpg 300w, https:\/\/www.brainpreservation.org\/wp-content\/uploads\/2015\/10\/BBPOffices.jpg 850w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><p id=\"caption-attachment-1469\" class=\"wp-caption-text\">Campus Biotech, offices of the Blue Brain Project of EPFL in Geneva, Switzerland<\/p><\/div>\n<p><span style=\"font-weight: 400;\">For example, Henry Markram\u2019s Blue Brain Project (BBP), mentioned above, is one leading computational neuroscience effort that seeks to emulate neural electrophysiology. It is largest slice of rat somatosensory cortex that has been emulated to date. In a recent minireview\u00a0of the BBP (see, <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26451478\" target=\"_blank\">A Biological Imitation Game, <\/a><\/span><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26451478\" target=\"_blank\"><i><span style=\"font-weight: 400;\">Cell <\/span><\/i><\/a><span style=\"font-weight: 400;\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26451478\" target=\"_blank\">2015 Oct 8;163(2):277-80<\/a>)<\/span><span style=\"font-weight: 400;\">, neuroscientists Christof Koch and Michael Buice of the Allen Instititute for Brain Science note that this emulation is an &#8220;impressive initial scaffold that will facilitate asking [specific and quantifiable] questions of brains.&#8221; The BBP may allow us to ask the deepest questions yet about what data are necessary to emulate cortex electrophysiology, and what data can be excluded. The BBP currently uses deterministic Hodgkin-Huxley partial differential equations as its &#8220;lowest level\u00a0of granularity&#8221; to represent neural firing activity. Koch and Buice ask whether, for example, stochastic Markov models of \u201cthousands of tiny [ion] channel conductances&#8221; might also be needed to model the subtleties of neural activity and coordination. The BBP simulation does not at present model ion channels, perhaps due to the current limitations of the IBM Blue Gene supercomputer they use for the emulation. It is important to note that the Markram team presently thinks that emulating ion channel detail will be unnecessary to reproduce neural electrophysiology. Koch and Buice point out that the only way to know if such detail is needed will be to conduct a Turing Test-like \u201c<a href=\"https:\/\/en.wikipedia.org\/wiki\/Turing_test#Imitation_Game\" target=\"_blank\">imitation game<\/a>.\u201d If the emulation gives the same response as wet neurophysiological experiments, at the level of system performance needed by the electrophysiologist, then the emulation has succeeded. Presumably such tests will be forthcoming from Markram\u2019s lab and others in coming years.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">What is not yet clear in these emulation efforts, perhaps because we don\u2019t yet know enough about neural information storage to even ask this question well, is what level of detail will be needed not only for electrophysiology emulation, but also for high-level memory encoding and retrieval. Fortunately, an \u201cimitation game\u201d for some of this kind of information is also being played today not only by <a href=\"https:\/\/en.wikipedia.org\/wiki\/Neuroscientist\" target=\"_blank\">neuroscientists <\/a>and\u00a0<a href=\"https:\/\/en.wikipedia.org\/wiki\/Computational_neuroscience\" target=\"_blank\">computational neuroscientists<\/a>, but also by <a href=\"https:\/\/en.wikipedia.org\/wiki\/Computer_scientist\" target=\"_blank\">computer scientists<\/a>, including those working with biologically-inspired architectures like <a href=\"https:\/\/en.wikipedia.org\/wiki\/Deep_learning\" target=\"_blank\">deep learning neural nets<\/a><\/span><span style=\"font-weight: 400;\">. Computer scientists are racing to figure out how to store high-level information like episodic memories in biologically-inspired associational networks on their own, computational neuroscientists are racing to emulate all neural activity, and neuroscientists\u00a0are racing to &#8220;imitate,&#8221; via better static and dynamic descriptions, all the remaining still-poorly-characterized features of neural structure and activity, such as <a href=\"https:\/\/en.wikipedia.org\/wiki\/Ephaptic_coupling\" target=\"_blank\">ephaptic coupling<\/a><\/span><span style=\"font-weight: 400;\">\u00a0and <a href=\"https:\/\/en.wikipedia.org\/wiki\/Perineuronal_net\" target=\"_blank\">perineuronal nets<\/a><\/span><span style=\"font-weight: 400;\">. <\/span><\/p>\n<div id=\"attachment_1481\" style=\"width: 285px\" class=\"wp-caption alignleft\"><a href=\"http:\/\/www.brainpreservation.org\/wp-content\/uploads\/2015\/10\/Perineuronalnets.png\"><img loading=\"lazy\" decoding=\"async\" aria-describedby=\"caption-attachment-1481\" class=\"size-medium wp-image-1481\" src=\"http:\/\/www.brainpreservation.org\/wp-content\/uploads\/2015\/10\/Perineuronalnets-275x300.png\" alt=\"Perineuronal Nets - Extracellular matrix structures responsible for synaptic stabilization in the adult brain (Wikipedia 2015).\" width=\"275\" height=\"300\" srcset=\"https:\/\/www.brainpreservation.org\/wp-content\/uploads\/2015\/10\/Perineuronalnets-275x300.png 275w, https:\/\/www.brainpreservation.org\/wp-content\/uploads\/2015\/10\/Perineuronalnets.png 440w\" sizes=\"auto, (max-width: 275px) 100vw, 275px\" \/><\/a><p id=\"caption-attachment-1481\" class=\"wp-caption-text\">Perineuronal Nets &#8211; Extracellular matrix structures responsible for synaptic stabilization in the adult brain (Wikipedia 2015).<\/p><\/div>\n<p><span style=\"font-weight: 400;\">Each of these races will inform each other, and at some point, we will know the subset of stable features and processes arising from neural anatomy (stable to all the chaos and trauma that affects live brains) that encode the high-level information we care about most. Perineuronal nets, for example, may regulate synaptic stability and our learning ability, but they may turn out not to be part of our stored learned knowledge itself. They may be one of those features of neural activity that we would like, but don\u2019t \u201cneed\u201d to emulate, for brain preservation to be a personally and socially valuable activity. As our knowledge advances, we will need to ask some important questions much better than we have been doing to date. <\/span><\/p>\n<p><span style=\"font-weight: 400;\">We will need to ask questions like: What kind of information in our own lives do we care most about preserving? If we were forced to choose, some of us might start with episodic memories, and move down from there to the hundreds of \u00a0distinct \u201c<a href=\"https:\/\/en.wikipedia.org\/wiki\/Modularity_of_mind\" target=\"_blank\">neural modules<\/a>\u201d<\/span><span style=\"font-weight: 400;\">\u00a0of cognition, emotion, and personality. Stated another way, if preservation services were affordable, accessible, and validated, and a few of your friends had already done it at the end of their own lives, how much of \u201cyou\u201d would you need to reasonably expect would be preserved in order to make the brain preservation choice? If you only had a reasonable expectation that your higher memories would be preserved, and nothing else, would that be enough? If you expected you would lose your perineuronal nets, due to (let us presume, for the sake of argument) damage to the extracellular matrix in the preservation process, and so expected be revived with all your unique memories, but the loss of your unique learning proclivities (being instead given \u201cspecies average\u201d perineuronal nets on your revival) would that be enough? If you were brought back like <a href=\"https:\/\/en.wikipedia.org\/wiki\/Henry_Molaison\" target=\"_blank\">Henry Molaison<\/a><\/span><span style=\"font-weight: 400;\">\u00a0after his hippocampal lesion, so that you had only your memories up to your death, and had to be given a hippocampal replacement (a \u201cspecies average\u201d module for your short-term memory), would that be enough? If you lost your <a href=\"https:\/\/en.wikipedia.org\/wiki\/Epigenome\" target=\"_blank\">epigenomic data<\/a>, and that turned out to take away, let&#8217;s say, 10% of the personality features\u00a0that made you different from your identical twin sibling (the other 90% of your differences being due to your unique memories and neural connections, which were successfully preserved), would that be enough? \u00a0If you could keep your cortical memories, but your emotional state would be reverted to an earlier \u201cyou\u201d on revival, would that be enough? Finally, and most importantly for some, how affordable and reliable can we make the various preservation\u00a0options, and can they be done sustainably with respect to the environment?<\/span><\/p>\n<p><span style=\"font-weight: 400;\">We believe brain preservation is a personal choice each of us should be able to freely make for ourselves, or not, in light of ever-changing science, technology, and self-understanding, at the point of our own deaths. Clearly, brain emulation will never be a perfect process. At best, it will attempt to statistically approximate perfection, as neuroscience and computer science get better at knowing what features of the <a href=\"https:\/\/en.wikipedia.org\/wiki\/Human_brain\" target=\"_blank\">most complex and fascinating material structures on Earth<\/a>, our brains, can be preserved, what features are \u201cworth\u201d preserving and reviving, and what features are not. The preservation option already exists today. Seeking to validate that option, or finding that it cannot be validated, is our <a href=\"http:\/\/www.brainpreservation.org\/mission\/\" target=\"_blank\">institutional mission<\/a>. The more we know, the more informed our choice can be.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Dr. Kenneth D. Miller, Co-Director of the Center for Theoretical Neuroscience at Columbia University, in a recent editorial in the New York Times,\u00a0\u201cWill You Ever Be Able to Upload Your Brain?\u201d, \u00a0recently raised several skeptical arguments about the possibility of brain uploading. A key point to take away from this essay is that Dr. Miller [&hellip;]<\/p>\n","protected":false},"author":13,"featured_media":1466,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"coauthors":[32,25,30],"class_list":["post-1462","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-brain-preservation"],"_links":{"self":[{"href":"https:\/\/www.brainpreservation.org\/zh\/wp-json\/wp\/v2\/posts\/1462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.brainpreservation.org\/zh\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.brainpreservation.org\/zh\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.brainpreservation.org\/zh\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.brainpreservation.org\/zh\/wp-json\/wp\/v2\/comments?post=1462"}],"version-history":[{"count":32,"href":"https:\/\/www.brainpreservation.org\/zh\/wp-json\/wp\/v2\/posts\/1462\/revisions"}],"predecessor-version":[{"id":1498,"href":"https:\/\/www.brainpreservation.org\/zh\/wp-json\/wp\/v2\/posts\/1462\/revisions\/1498"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.brainpreservation.org\/zh\/wp-json\/wp\/v2\/media\/1466"}],"wp:attachment":[{"href":"https:\/\/www.brainpreservation.org\/zh\/wp-json\/wp\/v2\/media?parent=1462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.brainpreservation.org\/zh\/wp-json\/wp\/v2\/categories?post=1462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.brainpreservation.org\/zh\/wp-json\/wp\/v2\/tags?post=1462"},{"taxonomy":"author","embeddable":true,"href":"https:\/\/www.brainpreservation.org\/zh\/wp-json\/wp\/v2\/coauthors?post=1462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}